Proof & Provenance: A federated biobank data platform for coordinating and sharing phages and results
Jan Zheng 1, 3, 4*, Ben Temperton 2, Jon Iredell 3, 4
- Phage Directory
- University of Exeter
- Phage Australia
- Westmead Institute for Medical Research
The purity and origin of bacteriophages are essential factors in microbiology research. While current databases are helpful, they don't fully meet the need for a thorough, easy-to-use platform for phage data. This abstract proposes a new approach to phage biobanking: a published collection of phages. In this system, shared Standard Operating Procedures (SOPs), wet lab data, and bioinformatics data would allow for independent assessment of a phage's quality, moving us closer to the goal of creating "Material Safety Data Sheets" for phages.
Phages are constantly evolving, which makes it necessary to track changes and variations in their characteristics. This includes important details such as transfer agreements, safety notes, host characteristics, and specific notes associated with each phage. These elements add to a phage's origin story, providing a clear record of its unique history and uses.
The proposed phage biobanking system goes beyond the traditional database model. It's a full-stack data application that securely manages and uploads a variety of data and file objects. It offers keyword search capabilities and gives users detailed control over how they can publish and share data. This system combines the easy-to-use nature of note-taking apps with the data-handling capabilities of spreadsheet software and the storage abilities of cloud storage services. It's also designed to be open-source and cost-effective.
The main goal of this project is to create a shareable, collaborative platform for phage biobanking that can be audited. By building each layer of the biobank data application stack, this system aims to improve the efficiency and thoroughness of phage biobanking, paving the way for advancements in microbiology.